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2C-B-FLY is a lesser-known novel psychedelic substance of the phenethylamine and benzodihydrodifuran classes that produces an array of psychedelic and entactogenic effects when administered. Reports have characterized its effects profile as possessing features of 2C-Bmescaline and MDA, with a duration of 6–8 hours (or up to 12 hours in larger doses).

2C-B-FLY is a derivative of the 2C-x family of psychedelic phenethylamines, specifically 2C-B, of which it significantly differs from in terms of its potency, metabolism, and potential toxicity. It was first synthesized by Aaron P. Monte in 1996.[1][2]

Around 2005, 2C-B-FLY appeared and gained some popularity in the online research chemicals market before largely disappearing in October 2009, when a batch of Bromo-DragonFLY was accidentally mislabeled as 2C-B-FLY (Bromo-DragonFLY is dosed in micrograms, where 2C-B-FLY is dosed in milligrams) led to two deaths as a result of taking overdoses of Bromo-DragonFLY meant to be effective doses for 2C-B-FLY.[3] This event led to its immediate withdrawal until around 2016, when it resurfaced on the market again.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-B-FLY, and it has little history of human usage. It has no documented history of being sold on the streets and is commercially distributed through online research chemical vendors.

Due to its high potency and sensitive dose-response, many reports also indicate that the effects of this substance should not be seen as a simple substitute for 2C-B. It is highly advised to approach this potent, long-lasting, and unpredictable hallucinogenic substance with the proper amount of precaution and harm reduction practices if choosing to use it.

History and culture

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In a 2007 MAPS newsletter interview, Ann Shulgin revealed that 2C-B-FLY as one of her favorite psychedelic substances while also acknowledging the high variability in responses it seemed to display.[4]

Chemistry

2C-B-FLY is a substituted molecule of the phenethylamine and dihydrobenzofuran chemical classes. 2C-B-FLY features a phenyl ring bound to an amino (NH2) group through an ethyl chain and contains a bromine atom attached to carbon R4 of the phenyl ring.

It is an atypical psychedelic phenethylamine which is closely analogous to 2C-B; it is the dihydrofuran analog to 2C-B, where it incorporates the methoxy groups bound to R2 and R5 of 2C-B into five-member dihydrofuran rings fused to the central benzene ring.

2C-B-FLY belongs to a group of phenethylamine derivatives referred to as the FLY compounds, named for their insect-like appearance of two “wing-like” tetrahydrofuran rings fused on the opposite sides of the central benzene ring. The incorporation of the two methoxy groups into the 5 member rings fixes them into the optimum position for binding to the receptors they interact with resulting in an increase in potency compared to the compound’s non-rigid counterpart 2C-B.[5]

Pharmacology

Further information: Serotonergic psychedelic

Little is known about how the totality of its effects are produced, 2C-B-FLY’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist.

However, the role of these interactions and how they result in the psychedelic experience remains subject to on-going scientific investigation.

Subjective effects

In comparison to 2C-B, this compound presents a significantly more pronounced body high/load, stronger visual effects, more complex geometry and more in-depth internal hallucinations which are comparable to mescaline2C-E or MDA at higher doses. Lower doses, however, are associated with more entactogenic as opposed to classical psychedelic effects.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be treated with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses are more likely to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death.

Physical effects

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Visual effects

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Cognitive effects

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After effects

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Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
We also recommend that you conduct independent research and use harm reduction practices when using this substance.

The toxicity and long-term health effects of recreational 2C-B-FLY do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-B-FLY is a research chemical with a very limited history of human usage.

Anecdotal evidence from people within the community who have tried 2C-B-FLY suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

2C-B-FLY is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-B-FLY are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-B-FLY presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-B-FLY all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research (e.g. GoogleDuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.

If 2C-B-FLY does have suspected MAO-altering effects, this could indicate that 2C-B-FLY is more likely to induce serotonin syndrome or general monoamine overload (especially at high dosages) than other serotonergic psychedelics.[7] This may make it dangerous to combine it with MAOIsstimulants and certain substances which modulate synaptic concentrations of neurotransmitters such as serotonindopamine and norepinephrine through unknown mechanisms. These substances include but are not limited to:

Legal status

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Austria: 2C-B-FLY is illegal to possess, produce and sell under the NPSG. (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
  • Canada: 2C-B-FLY would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[8]
  • Germany: 2C-B-FLY is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.[9][10] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[11]
  • Sweden: As of April 2018, 2C-B-FLY is illegal to possess, sell, buy and use under Swedish law.[12]
  • Switzerland: It is unclear whether 2C-B-FLY is in the scope of a substituted phenethylamine under Verzeichnis E point 130, since it is not an “alkyl, alkoxy, alkylenedioxy or halide derivative of phenethylamine”, while additionally containing further univalent substituents, according to the scope. Although it could theoretically be considered an alkoxy derivative, it would still miss one hydrogen atom on the alkyl part of the alkoxy substituent. It is also unclear if it can be considered a true ether analog of an ether analog of 2C-B which would make it controlled under Buchstabe C.[13]
  • Turkey: 2C-B-FLY is a classed as drug and is illegal to possess, produce, supply, or import.[14] [15]
  • United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[16]
  • United States: 2C-B-FLY is unscheduled and uncontrolled in the United States. However, it may fall under the scope of the Federal Analogue Act if it is intended for human consumption given its similarity to 2C-B.

See also

External links

Discussion

Literature

References

  1.  https://erowid.org/chemicals/2cb_fly/2cb_fly_info1.shtml
  2.  http://www.sciencedirect.com/topics/page/2C-B-FLY
  3.  Information on Reported Deaths Related to 2C-B-FLY | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml
  4.  http://www.maps.org/news-letters/v17n2/v17n2_annshulgin-23.pdf
  5.  http://heffter.org/docs/hrireview/01/chapter5.pdf
  6.  Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). “Dose-independent occurrence of seizure with tramadol”. Journal of Medical Toxicology5 (2): 63–67. doi:10.1007/BF03161089ISSN 1556-9039.
  7.  Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
  8.  Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
  9.  “Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe” (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 11, 2019.
  10.  “Anlage NpSG” (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
  11.  “§ 4 NpSG” (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
  12.  https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2018/februari/tio-nya-amnen-kan-klassas-som-narkotika-eller-halsofarlig-vara/
  13.  “Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien” (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020.
  14.  https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm
  15.  https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf
  16.  Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted
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