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5F MDMB PICA is a designer drug and synthetic cannabinoid.


5F MDMB PICA

5F MDMB PICA is a designer drug and synthetic cannabinoid.[1][2] In 2018, it was the fifth-most common synthetic cannabinoid identified in drugs seized by the Drug Enforcement Administration.[3]

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5F MDMB PICA is a potent agonist of both the CB1 receptor and the CB2 receptor with EC50 values of 0.45 nM and 7.4 nM, respectively.[4]

In the United States, 5F-MDMB-PICA is a Schedule I Controlled Substance.[5] In December of 2019, the UNODC announced scheduling recommendations placing 5F MDMB PICA into Schedule II.[6]

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5f mdmb pica References[edit]

  1. ^ Risseeuw MD, Blanckaert P, Coopman V, Van Quekelberghe S, Van Calenbergh S, Cordonnier J (April 2017). “Identification of a new tert-leucinate class synthetic cannabinoid in powder and “spice-like” herbal incenses: Methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA)”. Forensic Science International273: 45–52. doi:10.1016/j.forsciint.2017.01.023hdl:1854/LU-8542830PMID 28214755.

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  1. ^ Mogler L, Franz F, Rentsch D, Angerer V, Weinfurtner G, Longworth M, et al. (January 2018). “Detection of the recently emerged synthetic cannabinoid 5F-MDMB-PICA in ‘legal high’ products and human urine samples”. Drug Testing and Analysis10 (1): 196–205. doi:10.1002/dta.2201PMID 28371476.
  2. ^ “Emerging Threat Report: Annual 2018” (PDF). Special Testing and Research Laboratory, Drug Enforcement Administration.
  3. ^ Banister SD, Longworth M, Kevin R, Sachdev S, Santiago M, Stuart J, et al. (September 2016). “Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues”. ACS Chemical Neuroscience7 (9): 1241–54. doi:10.1021/acschemneuro.6b00137PMID 27421060.
  4. ^ “Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I”. Federal Register. 2019-04-16.
  5. ^ “December 2019 – WHO: World Health Organization recommends 12 NPS for scheduling”.
5F-MDMB-PICA
5F-MDMB-PICA.svg
Clinical data
Other names 5F-MDMB-2201; 5-Fluoro MDMB-PICA
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C21H29FN2O3
Molar mass 376.472 g·mol−1
3D model (JSmol)

 

5F-MDMB-PINACA. Report on the risk assessment of methyl 2-{[1-(5-fluoropentyl)-1H-indazole-3-carbonyl]amino}-3,3-dimethylbutanoate (5F-MDMB-PINACA) in the framework of the Council Decision on new psychoactive substances
Auteurs : OEDT = EMCDDA
Type de document : Rapport
Editeur : Lisbon : OEDT / EMCDDA, 2018
Autre Editeur : Luxembourg : Publications Office of the European Union
Collection : Risk assessments, ISSN 1725-4493, num. 25
Format : 64 p.
Langues: Anglais
Discipline : PRO (Produits, mode d’action, méthode de dépistage / Substances, action mode, screening methods)
Mots-clés : Thésaurus TOXIBASE

CANNABINOIDES ; CONTROLE DES STUPEFIANTS ; FACTEUR DE RISQUE ; DROGUES DE SYNTHESE ; PHARMACOLOGIE ; TYPE D’USAGE ; EFFET SECONDAIRE ; TOXICITE ; INTOXICATION ; MORTALITE ; SURVEILLANCE EPIDEMIOLOGIQUE ; AGONISTEThésaurus Géographique

EUROPEOrganismes

OEDT

Résumé : This publication presents the data and findings of the risk assessment on methyl 2-{[1-(5-fluoropentyl)-1H-indazole-3-carbonyl]amino}-3,3-dimethylbutanoate (5F-MDMB-PINACA), carried out by the extended Scientific Committee of the EMCDDA on 7-8 November 2017. In March 2018, at its 61st regular session, the Commission on Narcotic Drugs (CND) decided to place 5F-MDMB-PINACA in Schedule II of the Convention on Psychotropic Substances of 1971 based on a recommendation by the World Health Organization. This recommendation was substantially supported by European data provided by the EMCDDA.
Note de contenu : TABLE OF CONTENTS:
– Foreword.
– EMCDDA actions on monitoring and responding to new drugs.
– Europol-EMCDDA Joint Report on 5F-MDMB-PINACA (methyl 2-{[1-(5-fluoropentyl)-1H-indazole-3-carbonyl]amino}-3,3-dimethylbutanoate) – a summary.
– Risk Assessment Report on a new psychoactive substance: methyl 2-{[1-(5-fluoropentyl)-1H-indazole-3-carbonyl]amino}-3,3-dimethylbutanoate (5F-MDMB-PINACA).
– Technical report on methyl 2-{[1-(5-fluoropentyl)-1H-indazole-3-carbonyl]amino}-3,3-dimethylbutanoate (5F-MDMB-PINACA).
– Participants of the risk assessment meeting, 7-8 November 2017.
Domaine : Drogues illicites / Illicit drugs
Lien : http://www.emcdda.europa.eu/publications/risk-assessments/5f-mdmb-pinaca_en
– voir aussi :

5F-MDMB-PICA has been detected in products sold on the internet as well as in biological samples since 2016. It is associated with serious adverse health and behavioral effects and even death.

Herein we report on twelve cases with proven 5F-MDMB-PICA consumption, including three fatalities, four cases of driving under the influence of drugs and five other criminal acts. In these cases, 5F-MDMB-PICA was detected in postmortem blood or serum. Concentrations ranged from 0.1–16 ng/mL. In some blood (serum) and urine samples, the hydrolysis metabolite of 5F-MDMB-PICA (M12) could also be detected.

In this case series, co-consumption with other drugs occurred in 9 of 12 cases, most commonly alcohol, cannabis and other contemporary SCs. In five cases, 4F-MDMB-BINACA was also detected.

The described cases demonstrate various adverse effects that might be associated with 5F-MDMB-PICA. Observed physical adverse effects were mainly balance deficiencies and ocular effects such as reddened conjunctivae, glassy eyes and delayed or unresponsive pupil light reactions. Observed mental and behavioral effects were mainly changing moods, aggression, confusion, erratic behavior, mental leaps, disorientation, slowed reaction, logorrhea and slurred speech.

Due to the fast changing market of synthetic cannabinoids, data on such new appearing substances are basically scarce. Because of the limited number of studies on pharmacological properties of synthetic cannabinoids, reports of findings in human samples along with corresponding case history descriptions can be valuable for the interpretation of upcoming routine cases.

5F-MDMB-2201 is an indol-based synthetic cannbids,and very potent CB1/CB2 receptor agonist, is structurally related to MMB-2201.

5F-MDMB-2201 is a synthetic cannabinoid of the indazole family, and very closely related to the better known 5F-MDMB-PINACA. It is an indazole 3 carboxamide that is beginning to be seen in synthetic cannabis products around the world.

Properties of 5F-MDMB-2201

ProName: 5f-MDMB-2201

CasNo: 1715016-76-4

Molecular Formula: C17H13ClN4O

Appearance: white or yellow powder

Application: chemical research

DeliveryTime: at once received the payment

PackAge: Aluminum foil bag

Port: HongKong Shenzhen Shanghai port

Purity: 99.99%

Storage: in shade

Transportation: TNT, UPS, DHL, FEDEX, EMS and so on.

LimitNum: 5 Gram

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