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A PVP is similar to cocaine with lesser potency. It quickly dissolves when a user places it under the tongue, but he/she might experience a numb feeling.

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Description

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α-PVP (full name is:α-Pyrrolidinopentiophenone) also known as alpha-pyrrolidinovalerophenone, A-PVP, alpha-PVP, O-2387, APVP,,PVP,β-ketone-prolintane, Prolintanone). it is a synthetic stimulant drug of the cathinone class developed in the 1960s sometimes called flakka or gravel.

α-PVP  is chemically related to pyrovalerone and is the ketone analog of prolintane,and it is often used as a recreational drug, and is considered a Schedule I drug under the Food and Drug Administration Safety and Innovation Act.

Pyrovalerone is an inhibitor of the transporters for certain monoamine neurotransmitters, including dopamine and norepinephrine, preventing their uptake.1,2 α-Pyrrolidinopentiophenone (hydrochloride) is an analog of pyrovalerone, lacking only the methyl group that is found on the phenyl moiety of pyrovalerone. Like pyrovalerone, this compound is expected to be a psychoactive stimulant. This product is intended for forensic applications.

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a-PVP or Alpha-PVP smoking

It can be consumed by blending it with other substances. In addition, it can also be inhaled or consumed orally depending on the dosage and consumption. It is suggested not to

a-PVP or Alpha-PVP dosage(& Usage)

the Doses ranging from 10–25 mg was often taken by the researcher. 4-5mg is the threashold,the feeling of 5-10mg is light,10-25mg is common,and above 25mg,the feeling will be strong.
a-PVP or Alpha-PVP experience(effects)

Alpha-PVP is similar to cocaine with lesser potency. It quickly dissolves when a user places it under the tongue, but he/she might experience a numb feeling. The euphoria sets in slowly, about 30 minutes after consumption. The numbness in the tongue follows with a mild increase in blood pressure and completely no desire of drinking water.

After about 45 minutes of consumption, a mild stimulation is felt and the consumer might feel drowsy. All the effects last only for 3 hours and the user might not even feel the urge to consume another dose.

The Insufflation method makes a user experience an euphoric feeling for a long time. It is hard to determine its potency as some consumers get affected very slowly when they indulge in this method. It works immediately from the moment it enters the consumer’s nose. The state of euphoria is achieved within 10 minutes of consumption. Blackouts are felt frequently. And in an hour a person feels sleepy.

The high feeling caused when you buy Alpha – PVP and use it does not last long. Some users claim that consuming the crystal form is better than smoking it as it does not burn their nose. In addition, others have differentexperiences.An overwhelming experience lasts only 3 hours and the desire to consume to another dose depends on the consumer’s history with such stimulants.

The most important effect of this drug is that it improves the creative ability of the user. Other effects include a sense of extreme happiness and a high level of energy. The consumer’s body relaxes with no cravings for food.

It is advised to consume this drug in lower doses and be cautious about anincreased consciousness and hyponatremia and it can easily go out of control with higher dosage.

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a-PVP or APVP review

Earlier this month TPR noted that a relatively new second-generation bath salt call “gravel” was reported to have surfaced in various parts of the United States, including Tennessee. As background, while first-generation bath salts — MDPV, methylone, and mephedrone — were outlawed in many jurisdictions, new analogues had been introduced to replace them and were still generally legal. Samples of “gravel” contained α-PVP, an analogue of MDPV. It seemed to produce impressive degrees of paranoia. Some samples of the drug were adulterated with methamphetamine and/or clonazepam.

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This current study just posted online is thus a timely and important contribution to understanding this new drug. Using an in vivo and in vitro rat model, the authors sought to compare the effects of MDPV with those of its analogues, including α-PVP.

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Like MDPV, α-PVP contains a pyrrolidine ring, a 5-sided nitrogen-containing component that enables the molecule to effectively block reuptake of dopamαine and norepinephrine, with much weaker effects at the serotonin transporter.

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In rats, α-PVP produced evidence of psychomotor stimulation, with higher doses causing hyperactivity and bizarre behavior. A dopamine antagonist blocked much of the motor hyperactivity.

Although I tend to shy away from rat studies, I found this one important because it is one of the first studies of the effects of α-PVP (aka “gravel”).

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a-PVP vs MDPV

aPVP (alpha-PVP) vs. MDPV comparison:

These are two very similar chemicals in structure, based on pyrovalerone and resembling non-identical twins in their nature, or a “female” vs. “male” mallard duck… however, they both walk, look and quack like a duck, not a duck/crow (as an example) **.

Also, my qualifications: Regular and in-depth experience with MDPV practically since the day it came out in the early-mid 2000’s, and a recent introduction to aPVP via a well-trusted and reliable source.

MDPV (appearance): Powdery white-to-tan.
A-PVP: Clumpy tan to dark tan.

MDPV (odor): Mild “pyrrolidine” type odor (like smelly sweat-socks).
A-PVP: Heavier (moderate) “pyrrolidine” type odor.

MDPV (solubility): Dissolves in H2O with difficulty, mild “pyrrolidine” type odor in solution.
A-PVP: Dissolves readily, heavier (moderate) “pyrrolidine” type odor in solution.

MDPV (smokeability): Vapes somewhat uncleanly, mild to moderate harshness/odor.
A-PVP: Vapes very easily/cleanly, moderate to heavy harshness/odor.

MDPV (onset and duration): Slow to medium onset of effects, lesser dosage needed, greater duration.
A-PVP: Rapid onset of effects (all tested ROA’s), 1/4 to 1/3 greater dosage needed, lesser duration.

Summary (useful info): a-PVP vapes better than MDPV, but is harder on the lungs and harsher. Effects come on faster, but last a shorter period of time and more is needed than with MDPV. A “rush” is possible/likely with a-PVP (particularly if smoked or injected), and unlikely with MDPV.

The “highs” are otherwise quite similar — plain old NDRI (norepinephrine/dopamine) reuptake inhibition and stimulation with varying/unpredictable euphoria, an increase in sexual tendencies and unpleasant tweaking at higher dosages.

APVP “feels like” a cruder, harsher and less sophisticated (but faster-acting and smoother burning) version of MDPV. MDPV is like “high end/fancy/fussy” and aPVP is “low end, poor man, easy-going” version of the same thing.

Given the faster onset and shorter duration of effects, it is possible that a-PVP will be more compulsive than MDPV via rapid onset ROA’s (smoking, slamming), but it may take longer to take hold and have an easier/shorter comedown when the user regains willpower. Vapers may experience lung damage/pain with a-PVP (temporary, most likely, but who knows). It is likely (from my research, including contact with a professional source that suggests it) that a-PVP degrades/loses potency substantially faster than MDPV, whether in solution or not, and so care in storage is more of a factor.

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a-PVP or Alpha-PVP for sale

You can buy Alpha-PVP in best-feel.com online in select countries, depending on its legality. Our company is one of biggest suppliers in the market of designer drugs in China, we always provice the top quality products with the best prices!

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alpha-PVP is the ketone analog of prolintan, another stimulant, psychoactive substance that belongs to the cathinones.

Andere Namena-PVPα-PVPalpha-PVPalpha-Pyrrolidinopentiophenonalpha-Pyrrolidinopentiophenone (engl.), Î±-Pyrrolidinopentiophenonα-Pyrrolidinopentiophenone (engl.), O-2387ß-keto-prolintanß-keto-prolintane (engl.), ProlintanonProlintanone (engl.), Desmethyl PyrovaleronDesmethyl Pyrovalerone (engl.), FlakkaGravel2-(1-pyrrolidinyl)-Valerophenon2-(1-pyrrolidinyl)-Valerophenone (engl.)

IUPAC: (RS)-1-Phenyl-2-(1-pyrrolidinyl)-1-pentanon(RS)-1-Phenyl-2-(1-pyrrolidinyl)-1-pentanone (engl.)

SummenformelC15H21NO

Molekulare Masse231.333 g/mol

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a-PVP – There is not enough information about this substance!

Hardly any reports from consumers and certainly very few scientific papers.
Accordingly, the consumption is an unpredictable risk, possible toxic effects may be undetected.
We strongly advise against taking it! The following information is a collection of information taken from reports about this designer drug. We can not guarantee the accuracy and recommend to anyone to consult further sources.

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Effect of a-PVP

The effects and side effects listed here are all very subjective and are perceived differently by each person.
They do not always have to occur and there may be other, unmentioned effects. (Then we would be pleased about a comment on this!)

These lists should not serve as a guarantee, but as a guide.

Stimulation (stimulating, awakening) – alpha-PVP has a very strong stimulating effect, many consumers feel compelled to move or perform repetitive actions. Even more stimulating than, for example, amphetamine, 2-FA or 2-MMC!
Appetitzügelnd
Concentration and performance increase – The focus is greatly enhanced by this substance.
Aphrodisiac – increasing sexual desire and delaying orgasm, aphrodisiac activity is less pronounced in a-PiHP according to some consumers than in a-PVP or MDPV, but still quite strong.
Increased Rededrang – A so-called “Laberflash”
Euphoric – a-PVP is said to be less euphoric than MDPV, comparable to the euphoria of amphetamine or methamphetamine, perhaps. Depending on the set & setting and tolerance, the euphoria can hardly be found!
Increased self-confidence
Improved perception of music

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The effect of alpha-PVP is very similar to that of MDPV, so pyrovalerone analog typical. It is quite short and very intense, with many side effects, severe craving and more like methamphetamine than amphetamine.
Nevertheless, MDPV is much more popular than a-PVP because the euphoria in the latter should be less pronounced.

A-PVP is definitely one of the most stimulating, stimulating uppers, but also the most dangerous.

For many people, the effect is too intense and they find it very unpleasant, some like it and in those the addictiveness is very high.
It is extremely difficult to handle this substance responsibly!

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a-PVP dose / dosage

These dosage indications are only approximate guidelines derived from consumer reports.
It must be started with an allergy test and a very low dose!
More Safer Use rules can be found here.

Orally:

First effects from: 1-5mg
Light effect: 5-10mg
Normal: 8-25mg
Strong effect: 20-40mg
Very strong effect: 35mg +

Nasal:

First effects from: 0.5-1mg
Light effect: 1-5mg
Normal: 4-15mg
Strong effect: 12-25mg
Very strong effect: 20mg +

inhalation:

First effects from: 1-2mg
Slight effect: 2-5mg
Normal: 4-15mg
Strong effect: 12-25mg
Very strong effect: 25mg +

a-PVP reaction time

Orally:

Effect on after: 5-30 minutes
Main effect: 2-6 hours
Of which peak: 1-2 1/2 hours
Coming down: 1-5 hours
Afterglow: 4-12 hours

Nasal:

Effect on after: 2-30 minutes
Main effect: 2-5 hours
Of which peak: 20-45 minutes
Coming down: 30-90 minutes
Afterglow: 2-4 hours

inhalation:

Activation after: few seconds to minutes
Main effect: 30-60 minutes
Of which peak: 3-6 minutes
Coming down: 15-30 minutes
Afterglow: 1-3 hours

 

a-pvp development of tolerance

Tolerance formation is probably the same for α-PVP as for most other uppers.
Already one-time consumption increases the tolerance (with higher dose naturally correspondingly stronger than with low dosage), after 3-7 days it should be again in half, after 1-2 weeks completely reduced.

There is a cross tolerance with all other dopaminergic substances (ie all uppers, eg amphetamine, MDPV, 2-FA …).

a-PVP pharmacology

Alpha-PVP acts as a noradrenaline and dopamine reuptake inhibitor (norepinephrine: IC50 = 14.2nM, dopamine: IC50 = 12.8nM), which is very similar to the mechanism of action of MDPV.

In contrast to MDPV, however, a serotonin component is missing in a-PVP (in the case of alpha-PVP this is only very weak), which may be one reason for the lower euphoria in the latter.

So far, however, there are hardly any scientific studies, especially right to the effect on humans. Less than MDPV!

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