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U50488

U50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects.[1] It has analgesicdiuretic and antitussive effects,[2] and reverses the memory impairment produced by anticholinergic drugs.[3] U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds.[4][5] This compound has never received FDA approval and there are no reported human cases in the literature involving an U-50488 overdose.[6]

U50488 References[edit]

  1. ^ Von Voigtlander PF, Lewis RA (1982). “U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists”. Progress in Neuro-Psychopharmacology & Biological Psychiatry6 (4–6): 467–70. doi:10.1016/S0278-5846(82)80130-9PMID 6298890S2CID 37011292.
  2. ^ Kamei J (1996). “Role of opioidergic and serotonergic mechanisms in cough and antitussives”. Pulmonary Pharmacology9 (5–6): 349–56. doi:10.1006/pulp.1996.0046PMID 9232674.
  3. ^ Hiramatsu M, Kameyama T (September 1998). “Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models”. Methods and Findings in Experimental and Clinical Pharmacology20 (7): 595–9. doi:10.1358/mf.1998.20.7.485724PMID 9819804.
  4. ^ Szmuszkovicz J (1999). “U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990”. Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques52: 167–95. doi:10.1007/978-3-0348-8730-4_4PMID 10396128.
  5. ^ Szmuszkovicz J (1999). “U-50,488 and the kappa receptor. Part II: 1991-1998”. Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques53: 1–51. PMID 10616295.
  6. ^ Amin ZM, Rambaran KA, Fleming SW, Cho K, Chacko L, Alzghari SK (December 2017). “Addressing Hazards from Unscheduled Novel Psychoactive Substances as Research Chemicals: The Case of U-50488”Cureus9 (12): e1914. doi:10.7759/cureus.1914PMC 5800751PMID 29441248.

Quick Details

  • ProName: stronger u50488 supplier high purity
  • CasNo: 82657-23-6
  • Molecular Formula: NONE
  • Appearance: Powder and crytal
  • Application: For lab or chemical research
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  • ProductionCapacity: 50 Kilogram/Day
  • Purity: 99.8%
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  • LimitNum: 10 Gram
  • Moisture Content: <0.05%
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