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U50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects. It has analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs. U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds. This compound has never received FDA approval and there are no reported human cases in the literature involving an U-50488 overdose.
- Von Voigtlander PF, Lewis RA (1982). “U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists”. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 6 (4–6): 467–70. doi:10.1016/S0278-5846(82)80130-9. PMID 6298890. S2CID 37011292.
- Kamei J (1996). “Role of opioidergic and serotonergic mechanisms in cough and antitussives”. Pulmonary Pharmacology. 9 (5–6): 349–56. doi:10.1006/pulp.1996.0046. PMID 9232674.
- Hiramatsu M, Kameyama T (September 1998). “Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models”. Methods and Findings in Experimental and Clinical Pharmacology. 20 (7): 595–9. doi:10.1358/mf.1922.214.171.1245724. PMID 9819804.
- Szmuszkovicz J (1999). “U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990”. Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques. 52: 167–95. doi:10.1007/978-3-0348-8730-4_4. PMID 10396128.
- Szmuszkovicz J (1999). “U-50,488 and the kappa receptor. Part II: 1991-1998”. Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques. 53: 1–51. PMID 10616295.
- Amin ZM, Rambaran KA, Fleming SW, Cho K, Chacko L, Alzghari SK (December 2017). “Addressing Hazards from Unscheduled Novel Psychoactive Substances as Research Chemicals: The Case of U-50488”. Cureus. 9 (12): e1914. doi:10.7759/cureus.1914. PMC 5800751. PMID 29441248.
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|Chemical and physical data|
|Molar mass||369.33 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
- ProName: stronger u50488 supplier high purity
- CasNo: 82657-23-6
- Molecular Formula: NONE
- Appearance: Powder and crytal
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